Neurophysiology of Alzheimer’s Disease

Original Research:

Lam AD*, Sarkis RA*, Pellerin KR, Jing J, Dworetzky BA, Hoch DB, Jacobs CS, Lee JW, Weisholtz DS, Zepeda R, Westover MB, Cole AJ, Cash SS. Association of epileptiform abnormalities and seizures in Alzheimer disease. Neurology. 2020 Oct 20;95(16):e2259-e2270. PMID: 32764101. *Co-first authors. PDF

Ye E, Sun H, Leone MJ, Paixao L, Thomas RJ, Lam AD*, Westover MB*. Association of Sleep EEG-based Brain Age Index with Dementia. JAMA Network Open. 2020 Sep 1;3(9): e2017357. PMID: 32986106. * Co-senior authors. PDF

Brown R*, Lam AD*, Gonzalez-Sulser A*, Ying A, Jones M, Chou RC, Tzioras M, Jordan CY, Jedrasiak-Cape I, Hemonnot A, Abou Jaoude M, Cole AJ, Cash SS, Saito T, Saido T, Ribchester RR, Hashemi K, Oren I. Circadian and brain state modulation of network hyperexcitability in Alzheimer’s disease. eNeuro. 2018. 5(2) e0426-17.2018: 1-16. PMID 29780880. *Co-first authors. PDF

Lam AD, Deck G, Goldman A, Eskandar EN, Noebels J, Cole AJ. Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer’s disease. Nature Medicine. 2017 Jun;23(6):678-680. PMID: 28459436. PDF Supplement

Reviews / Commentaries:

Lam AD, Shafi MM. Towards a coherent view of network hyperexcitability in Alzheimer’s Disease. Brain. 2022 Apr 18; 145(2):423-425. PMID: 35259227. PDF

Lam AD, Noebels J. Nightwatch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease. Epilepsy Currents. Nov-Dec 2020; 20(6):369-374. PMID: 33081517. PDF

Lam AD, Cole AJ, Cash SS. New Approaches to Studying Silent Mesial Temporal Lobe Seizures in Alzheimer’s Disease. Frontiers in Neurology. 2019 Sept 4; 10:959. PMID: 31551916. PDF

Research Highlights:

Faught E.  Restoring EEG to its Rightful Place in Alzheimer Disease Care.  Epilepsy Currents. 2021 Mar 9; 21(3):175-176. PMID: 34867098.  

Harden C. Epilepsy and Alzheimer’s Disease: Ubiquitous Entities Subject to the Same Cosmic Forces but on Different Astral Planes. Epilepsy Currents. 2018 Sep-Oct; 18(5): 295-297. PMID: 30464726.

Burke JF, Peters A, Rolston JD. Intracranial Electroencephalography for Alzheimer’s. Neurosurgery. 2017 Sep 1; 81(3):N23-N24. PMID: 28859460.

Detecting Silent Epileptiform Activity

Original Research:

Abou Jaoude M, Jacobs CS, Sarkis RA, Jing J, Pellerin KR, Cole AJ, Cash SS, Westover MB, Lam AD. Noninvasive Detection of Hippocampal Epileptiform Activity on Scalp Electroencephalogram. JAMA Neurology. 2022 Jun 1; 79(6):614-622.  PMID: 35499837.  PDF

Abou Jaoude M, Sun H, Pellerin KR, Pavlova M, Sarkis RA, Cash SS, Westover MB*, Lam AD*. Expert-level automated sleep staging of long-term scalp EEG recordings using deep learning. Sleep. 2020 Nov 12; 43(11):zsaa112. PMID: 32478820. *Co-senior authors PDF   Sleep Staging Algorithm

Abou Jaoude M, Jing J, Sun H, Jacobs CS, Pellerin KR, Westover MB, Cash SS, Lam AD. Detection of mesial temporal lobe epileptiform discharges on intracranial electrodes using deep learning. Clinical Neurophysiology. 2020; 131(1):133‐141. PMID: 31760212. PDF

Lam AD, Maus D, Zafar SF, Cole AJ, Cash SS. SCOPE-mTL: A non-invasive tool for identifying and lateralizing mesial temporal lobe seizures prior to scalp EEG ictal onset. Clinical Neurophysiology. 2017 Sep; 128(9): 1647-1655. PMID: 28732342. PDF

Lam AD, Zepeda R, Cole AJ, Cash SS. Widespread changes in network activity allow non-invasive detection of mesial temporal lobe seizures. Brain. 2016 Oct;139(Pt 10):2679-2693. PMID: 27474219. PDF

Research Highlights:

Fyfe I. Epilepsy: Noninvasive detection of deep brain seizures. Nature Reviews Neurology. 2016;12(9):492-493. PMID: 27514286.

Szaflarski JP. The Man Versus the Machine: The Machine Wins the Race to Detect the Scalp-Negative Seizures. Epilepsy Currents. 2017 May-Jun; 17(3) 142-143. PMID: 28684942.


Johnson EL, Krauss GL, Kucharska-Newton A, Lam AD, Sarkis R, Gottesman RF.  Mortality in Patients With Late-Onset Epilepsy: Results from the Atherosclerosis Risk in Communities Study.  Neurology. 2021 Sep 14; 97(11):e1132-e1140.  PMID: 34282048.  

Babiloni C, Arakaki X, Azami H, Bennys K, Blinowska K, Bonanni L, Bujan A, Carrillo MC, Cichocki A, de Frutos-Lucas J, Del Percio C, Dubois B, Edelmayer R, Egan G, Epelbaum S, Escudero J, Evans A, Farina F, Fargo K, Fernández A, Ferri R, Frisoni G, Hampel H, Harrington MG, Jelic V, Jeong J, Jiang Y, Kaminski M, Kavcic V, Kilborn K, Kumar S, Lam A, Lim L, Lizio R, Lopez D, Lopez S, Lucey B, Maestú F, McGeown WJ, McKeith I, Moretti DV, Nobili F, Noce G, Olichney J, Onofrj M, Osorio R, Parra-Rodriguez M, Rajji T, Ritter P, Soricelli A, Stocchi F, Tarnanas I, Taylor JP, Teipel S, Tucci F, Valdes-Sosa M, Valdes-Sosa P, Weiergräber M, Yener G, Guntekin B.  Measures of resting state EEG rhythms for clinical trials in Alzheimer’s disease: Recommendations of an expert panel.  Alzheimers Dement. 2021 Sep; 17(9):1528-1553.  PMID: 33860614.  

Nascimento FA, Laze J, Friedman D, Lam A, Devinsky O.  SUDEP education among U.S. and international neurology trainees.  Epilepsy Behav. 2021 Aug;121(Pt A):108098.  PMID: 34111766.  

Yang JC, Harid NM, Nascimento FA, Kokkinos V, Shaughnessy A, Lam AD, Westover MB, Leslie-Mazwi TM, Hochberg LR, Rosenthal ES, Cole AJ, Richardson RM, Cash SS.  Responsive neurostimulation for focal motor status epilepticus.  Ann Clin Transl Neurol. 2021 Jun;8(6):1353-1361.  PMID: 33955717.  

Kirabira J, Lam A, Ssuna B, Rukundo GZ. Psychiatric disorders among children and adolescents with active epilepsy in southwestern Uganda. PAMJ – One Health. 2020 Oct 27; 3(9): DOI: 10.11604/pamj-oh.2020.3.9.25146.

Jing J, Sun H, Kim JA, Herlopian A, Karakis I, Ng M, Halford JJ, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Dauwels J, Lam A, Cole AJ, Cash SS, Westover MB. Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation. JAMA Neurology. 2020 Jan 1;77(1):103-108. PMID: 31633740.

Jing J, Herlopian A, Karakis I, Ng M, Halford JJ, Lam A, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Sun H, Dauwels J, Cole AJ, Hoch DB, Cash SS, Westover MB. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms. JAMA Neurology. 2020 Jan 1;77(1):49-57. PMID: 31633742.

Williams JA, Cisse FA, Schaekermann M, Sakadi F, Tassiou NR, Hotan GC, Bah AK, Hamani ABD, Lim A, Leung ECW, Fantaneanu TA, Milligan TA, Khatri V, Hoch DB, Vyas MV, Lam AD, Cohen JM, Vogel AC, Law E, Mateen FJ; Guinea Epilepsy Project. Smartphone EEG and remote online interpretation for children with epilepsy in the Republic of Guinea: Quality, characteristics, and practice implications. Seizure. 2019 Oct; 71:93-99. PMID 31229939.

McKenzie ED, Lim AS, Leung EC, Cole AJ, Lam AD, Eloyan A, Nirola DK, Tshering L, Thibert R, Garcia RZ, Bui E, Deki S, Lee L, Clark SJ, Cohen JM, Mantia J, Brizzi KT, Sorets TR, Wahlster S, Borzello M, Stopczynski A, Cash SS, Mateen FJ. Validation of a smartphone-based EEG among people with epilepsy: A prospective study. Sci Rep. 2017 Apr 3; 7:45567. PMID: 28367974.

McKenzie ED, Nirola DK, Deki S, Tshering L, Patenaude B, Clark SJ, Cash SS, Thibert R, Zepeda R, Leung EC, Lam AD, Lim AS, Mantia J, Cohen J, Cole AJ, Mateen FJ. Medication prescribing and patient-reported outcome measures in people with epilepsy in Bhutan. Epilepsy Behav. 2016 Jun;59:122-127. PMID: 27131914.

Mukerji SS, Lam AD, Wilson MR. Eastern equine encephalitis treated with intravenous immunoglobulin. Neurohospitalist. 2016 Jan;6(1):29-31. PMID: 26740855.

McGrath ER, Bathra A, Lam AD, Rizzo JF 3rd, Cole AJ. Clinical reasoning: A 64-year-old man with visual distortions. Neurology. 2016 Nov 22;87(21):e252-256. PMID: 27872229.

Blast from the Past!

Ben-Simon Y, Rodenas-Ruano A, Alvina K, Lam AD, Stuenkel EL, Castillo PE, Ashery U. A combined optogenetic-knockdown strategy reveals a major role of tomosyn in mossy fiber synaptic plasticity. Cell Rep. 2015 Jul 21;12(3):396-404. PMID: 26166572.

Bielopolski N, Lam AD, Bar-On D, Sauer M, Stuenkel EL, Ashery U. Differential interaction of tomosyn with syntaxin and SNAP25 depends on domains in the WD40 β-propeller core and determines its inhibitory activity. J Biol Chem. 2014 Jun 13;289(24):17087-17099. PMID: 24782308.

Williams AL, Bielopolski N, Meroz D, Lam AD, Passmore DR, Ben-Tal N, Ernst SA, Ashery U, Stuenkel EL. Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation. J Biol Chem. 2011 Apr 22;286(16):14542-14553. PMID: 21330375.

Lam AD, Ismail S, Wu R, Yizhar O, Passmore DR, Ernst SA, Stuenkel EL. Mapping dynamic protein interactions to insulin secretory granule behavior with TIRF-FRET. Biophys J. 2010 Aug 9;99(4):1311-1320. PMID: 20713017.

Lam AD, Tryoen-Toth P, Tsai B, Vitale N, Stuenkel EL. SNARE-catalyzed fusion events are regulated by Syntaxin1A-lipid interactions. Mol Biol Cell. 2008 Feb;19(2):485-497. PMID: 18003982.

Gladycheva SE*, Lam AD*, Liu J, D’Andrea-Merrins M, Yizhar O, Lentz SI, Ashery U, Ernst SA, Stuenkel EL. Receptor-mediated regulation of tomosyn-syntaxin 1A interactions in bovine adrenal chromaffin cells. J Biol Chem. 2007 Aug 3;282(31):22887-22899. PMID: 17545156. *Co-first authors.

D’Andrea-Merrins M, Chang L, Lam AD, Ernst SA, Stuenkel EL. Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking. J Biol Chem. 2007 Jun 1;282(22):16553-16566. PMID: 17412693.

Lam AD, Chikina MD, McNulty MM, Glaaser IW, Hanck DA. Role of Domain IV/S4 outermost arginines in gating of T-type calcium channels. Pflugers Arch. 2005 Nov;451(2):349-361. PMID: 16133267.

Khan A, Romantseva L, Lam A, Lipkind G, Fozzard HA. Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block. J Physiol. 2002 Aug 15;543(Pt 1):71-84. PMID: 12181282.